Traditional microfluidics has a scaling problem.

In conventional microfluidic manufacturing, each production unit needs its own pump, its own tubing, its own connections. Like early telephone switchboards, every new line requires manual wiring.

Telephone switchboard
Early switchboards required a physical connection for every call. Conventional microfluidics works the same way.

Traditional scale-up means more hardware.

Each additional unit needs its own pump and plumbing. Complexity, cost, and failure points grow with every step.

1 pump, 1 chip
PUMP OUT

Simple. Clean. Works at lab scale.

Manageable ✓

2 pumps, 2 chips, 2× tubing
PUMP PUMP

Double everything. Double cost, double failure points.

Difficult ⚠

100×

100 pumps, 100 chips, 300+ tubes
100 pumps 100 chips

Hundreds of pumps, chips, tubes. Quality control impossible. Cost prohibitive.

Impossible ✕

InfiniFluidics doesn't scale up.
We scale out.

Borrowing from semiconductor logic, VLSMI integrates more units onto the chip itself. Throughput increases. Pumps stay the same. Tubing stays the same. Quality stays identical.

Single unit
10×
Same chip format
1,000×
Larger chip
10,000×
Full wafer scale

Very Large Scale Microfluidic Integration

Thousands of microfluidic devices. One chip. One name.

Modular generators. Consistent quality.

The platform stays the same. Swap the generator for your application.

InfiniFluidics
VLSMI Platform
The chip stays constant
+

LNP Generator

Double Emulsion

Janus

Hydrogel

Custom

Throughput scales linearly with units on chip. Quality stays constant.

0.001 L 1 L 10 L Throughput (L/hr) Scale (units on chip) 10× 100× 10,000× Throughput ↑ CQAs (constant)

10,260 generators. Fits in your pocket.

Originally developed at the University of Pennsylvania in 2018, the VLSMI platform has been refined through multiple generations. One chip. One inlet. One outlet. Thousands of identical particles.

VLSMI wafer with 10,260 generators
VLSMI silicon wafer (Gen 4, 2018). Quarter for scale. Developed at Penn.

Ready to put this technology to work?

From discovery through commercial GMP, VLSMI grows with you.

Get in Touch →