AIR
AIRFoundry
2nd Annual Meeting & Facility Grand Opening
AIRFoundry celebrates its facility grand opening, highlighting advances in RNA manufacturing and InfiniFluidics' role.
PENN
Penn Engineering
$18M NSF AIRFoundry to Revolutionize RNA Research
NSF-funded BioFoundry integrating AI, microfluidics, and RNA science. InfiniFluidics is a core manufacturing partner.
PENN
Penn Engineering
Penn Engineers Secure Wellcome Leap Contract for Lipid Nanoparticle Research
Multi-million dollar contract under the $60M RNA Readiness + Response program for on-demand LNP manufacturing.
KBR
Korea Biomedical Review
COREE Partners with Infini Fluidics to Develop New mRNA Vaccine-Making Method
COREE and InfiniFluidics collaborate on advanced microfluidic manufacturing technology for mRNA vaccine production.
PENN
Penn Engineering
With a 'Liquid Assembly Line,' Penn Researchers Produce mRNA-Delivering Nanoparticles 100× Faster
128 parallel mixing channels produce LNPs with 4-5× greater activity in mice. VLSMI platform enables industrial-scale mRNA therapeutics.
PENN
Penn Today
A Faster Way to Make Drug Microparticles
Yadavali and Issadore introduce the VLSMI chip: 10,260 generators producing 1 trillion+ droplets per hour.
Advanced Functional Materials, 2024
Micro-Patterning Wettability in Very Large Scale Microfluidic Integrated Chips for Double Emulsion Generation
Lithographic wettability patterning for silicon/glass VLSMI chips, enabling both W/O/W and O/W/O double emulsions with parallelized generation at scale.
DOI: 10.1002/adfm.202309718
Nano Letters, 2021
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
VLSMI for LNP production with 128 parallel mixing channels. 100x throughput increase. 4-5x greater activity in mouse studies versus conventional methods.
DOI: 10.1021/acs.nanolett.1c01353
ACS Sustainable Chemistry & Engineering, 2020
Scalable Synthesis of Janus Particles with High Naturality
Scalable synthesis of plant-derived Janus particles using single-emulsion polymerization, demonstrated at scale with a VLSMI silicon-glass microfluidic device.
DOI: 10.1021/acssuschemeng.0c04929
Lab on a Chip, 2019
Large-Scale Production of Compound Bubbles Using Parallelized Microfluidics for Efficient Extraction of Metal Ions
Parallelized microfluidic production of compound bubbles at scale for efficient metal ion extraction applications.
DOI: 10.1039/C8LC01267A
Scientific Reports, 2019
Robust Microfabrication of Highly Parallelized Three-Dimensional Microfluidics on Silicon
Robust 3D microfabrication method for highly parallel microfluidics on silicon, enabling simultaneous operation of thousands of devices on a single chip.
DOI: 10.1038/s41598-019-48515-4
Nature Communications, 2018
Silicon and Glass Very Large Scale Microfluidic Droplet Integration for Terascale Generation of Polymer Microparticles
Introduced the VLSMI platform: 10,260 flow-focusing generators on a single silicon wafer producing 1 trillion+ droplets per hour with CV below 3%.
DOI: 10.1038/s41467-018-03515-2
Chemistry of Materials, 2018
Moldable Perfluoropolyether–PEG Networks with Tunable Wettability and Solvent Resistance for Rapid Prototyping of Droplet Microfluidics
Solvent-resistant PFPE-PEG elastomer networks enabling both W/O and O/W emulsion generation in microfluidic devices with organic solvents.
DOI: 10.1021/acs.chemmater.7b05043
Lab on a Chip, 2017
Liter-Scale Production of Uniform Gas Bubbles via Parallelization of Flow-Focusing Generators
Parallelized flow-focusing generators for liter-scale production of highly uniform gas bubbles with applications in functional materials synthesis.
DOI: 10.1039/C7LC00295E
Lab on a Chip, 2015
Kilo-Scale Droplet Generation in Three-Dimensional Monolithic Elastomer Device (3D MED)
Early demonstration of kilo-scale parallelized droplet generation using a 3D monolithic elastomer device, a precursor to the VLSMI platform.
DOI: 10.1039/C5LC01025J